|
KMID : 0378019800230080079
|
|
New Medical Journal
1980 Volume.23 No. 8 p.79 ~ p.84
|
|
|
Clinical Experience of Fluphenazine Decanoate (Ⅱ)
|
|
|
|
|
Abstract
|
|
|
Successful maintenance therapy with Fluphenazine decanoate depends substantially upon the prevention of painful extrapyramidal side reactions. In the previous report, one ´f the authors tried to develope a new technique for minimizing the extrapyramidal side reactions in converting of oral antipsychotic medications to the depot form. Oral medication was switched to the depot form after actue symptoms subsided and after the calculated depot dosage was less than Ice (25mg). Initially a shot of 0. ice was given. Then if further dosage was needed, after two hours 0. ice or 0. 2cc was given. The remainder, when further dosage was required, was given on the 7th day with careful evaluation of adverse reactions. This method of conversion resulted in successful maintenance therapy and decreased the incidence of extrapyramidal symptoms.
This report, a successive clinical trial to the previous report, was to evaluate the incidence of extrapyramidal symptoms between the group treated with the above mentioned method (Group B) and the group treated with Ayd´s method (group A) that in converting dosage of oral medications to the depot, full estimated dose of fluphenazine decanoate was given for the initial shot after two days of clearance of the oral medications.
The subject was 81 schizophrenics; 44 cases of group A, 37 of group B. DiMascio´s rating scale was used for evaluation of extrapyramidal symptoms.
Incidence of extrapyramidal symptoms such as rigid facial expression, tremor, akinesia, rigity, akathisia and dystonia was 56.2% in the group A and 18.9% in the group B.
When converting oral antipsychotic into the depot form, it has been a conventional practice to give the full estimated dose in a single injection from the start. But, for a safe dosage regimen in such occasion, it is recommended to start the regimen with a very small test dose and to increase gradually up to icc as required.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|